Role of medial prefrontal cortex serotonin 2A receptors in recognition memory in rodents – Professor Noelia Weisstaub, Faculty of Exact and Natural Sciences of the University of Buenos Aires

November 6, 2020 @ 4:30 pm – 6:00 pm
Zoom meeting
Louise White

Episodic memories contain information about our personal experiences. But memories would be useless if we could not retrieve them. Memory retrieval requires the correct selection of a particular trace to be expressed. However, many memories share cues, so how does the brain control interference between similar memories during retrieval? A system including the medial Prefrontal Cortex (mPFC) has been proposed to mediate response selection and control interference. Over the years we have studied how serotonin and particularly 5-HT2a receptors
(5-HT2aR) modulates memory processes. By combining behavioral tasks with pharmacology and genetically modified mice we were able to show that mPFC 5-HT2aR are important for the retrieval of episodic like memories and their reconsolidation, some of the signaling cascade that appears to participate in this modulation and how mPFC 5-HT2aR might help the retrieval of weak memories.

Noelia Weisstaub is a biologist from the Faculty of Exact and Natural Sciences of the University of Buenos Aires, 2 masters followed by PhD from Columbia University in New York (USA) with Dr Rene Hen and Dr Jay Gingrich, where she explored the role of the 5-HT2a receptor in emotional control processes and the action of hallucinogenic drugs. She followed with a postdoc in the Division of Translational Neurosciences of the Psychiatric Institute of New York. She returned to Argentina within the roots program for repatriation of human resources (PRH), first with a reintegration scholarship from CONICET and then as a full independent researcher In 2009 laboratory within the Systems Neuroscience Group at the School of Medicine of the University of Buenos Aires. She co-directs the Molecular Cognition Laboratory. The research lines of the laboratory are intended to understand the cellular and molecular and systems mechanisms of memory and forgetting and the role of the serotonergic system in these processes.

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